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Therapeutic Oligonucleotides for Preclinical Development

ASOs and siRNAs for Early Drug Discovery and in Vivo Testing

 

Custom ASO and siRNA synthesis for therapeutic applications

Microsynth provides high-quality therapeutic oligonucleotides, including antisense oligonucleotides (ASOs), gapmers and siRNAs, to support drug discovery and preclinical development as a reliable partner for custom oligonucleotide synthesis, advanced modifications and scalable manufacturing.

Our optimized synthesis platforms enable custom oligonucleotide manufacturing with advanced modifications, scalable production and reliable performance for demanding therapeutic programs.



Applications

  • Drug discovery and target validation
  • Lead optimization
  • In vivo studies
  • Preclinical development

Why Choose Microsynth?

  • Low endotoxin oligonucleotides (<0.5 EU/mg)
  • Broad expertise in ASO and siRNA chemistries
  • Scalable production from screening to preclinical quantities
  • Advanced modification and conjugation options
  • High-quality synthesis with MALDI-TOF MS and HPLC control
  • Fast and reliable turnaround times

👉 Discuss your therapeutic oligo project with our experts or request a quote for your ASO or siRNA program.

Low Endotoxin ASOs and siRNAs

Microsynth offers dedicated processes for the production of low endotoxin oligonucleotides, ensuring reliable performance in in vivo applications.

  • Endotoxin levels <0.5 EU/mg
  • Internal testing and reporting
  • Suitable for preclinical studies

Scalable Manufacturing

We support your project across all development stages:

  • Screening and discovery (µg–mg)
  • Lead optimization
  • Preclinical scale production

Our flexible manufacturing processes enable seamless scale-up as your project progresses.

Advanced Modifications and Conjugations

Microsynth supports a broad range of therapeutic oligo chemistries:

  • 2'-OMe, 2'-MOE, LNA, 2'-F, S-cEt
  • Phosphorothioate (PTO), mesyl (µ), phosphoryl guanidine (PN)
  • GalNAc and lipid conjugates
  • Custom modifications on request

These enable optimization of stability, delivery, and pharmacokinetics for therapeutic applications.

Quality and Documentation

  • Analytical HPLC and MALDI-TOF / ESI-MS
  • Certificates of Analysis
  • Endotoxin testing reports
  • ISO 9001 and ISO 13485 compliant processes

Workflow Support

We support your project from early discovery to preclinical development with tailored solutions and dedicated project support.

  1. Design and sequence optimization
  2. Custom synthesis and modification
  3. Scale-up and manufacturing
  4. Delivery for preclinical testing

 

How to Get Started

Contact our experts to discuss your therapeutic oligonucleotide program and receive a tailored solution.
Request a quote for your ASO or siRNA project and accelerate your drug discovery workflow.

Frequently Asked Questions

What are therapeutic oligonucleotides used for?

They enable targeted modulation of RNA, allowing treatment strategies for diseases that are difficult to address with traditional drugs.

Do you offer low endotoxin oligonucleotides?

Yes, Microsynth provides low endotoxin ASOs and siRNAs suitable for preclinical in vivo studies.

Can Microsynth support scale-up?

Yes, production can be scaled from screening to preclinical quantities with consistent quality.