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ASO and siRNA Design Services
Design tools and expert support for therapeutic oligonucleotides
Microsynth provides design tools and expert support for antisense oligonucleotides (ASOs) and siRNAs, enabling efficient screening and early-stage therapeutic development.
For standard applications, our online tools support fast and reliable design. For more complex projects, our experts provide dedicated design services, including siRNA design tools for screening and expert support for ASO design and complex therapeutic projects.
Applications
- siRNA and ASO screening
- Target validation and lead identification
- Early-stage therapeutic development
- Complex antisense design projects
Design Options Depending on Project Complexity
Low-complexity design (self-service)
For standard siRNA projects, our online design tool allows you to generate and evaluate candidate sequences directly in the webshop.
- Automated design suggestions
- Ranking based on Reynolds scoring
- Integrated BLAST for off-target assessment
- Ready-to-order output
👉 Design your siRNA directly in the webshop
High-complexity design (expert service)
ASO design and advanced siRNA projects require deeper expertise due to sequence accessibility, RNA structure and modification strategy.
Microsynth provides dedicated support for complex projects:
- ASO sequence design and screening strategy
- Selection of target regions and accessible sites
- Optimization of backbone and sugar modifications
- Support for gapmers, splice modulation and advanced chemistries
- Troubleshooting and redesign of existing candidates
This service is tailored to your project and offered as a paid expert service.
Why Choose Microsynth Design Services?
- More than 10 years of experience in ASO and siRNA design
- Functional guarantee for ASO design proposals
- Combination of bioinformatics tools and practical experience
- Seamless transition from design to oligonucleotide synthesis
- Support for complex therapeutic applications
👉 Discuss your ASO or siRNA design project with our experts or request a quote for advanced design support.
Design Workflow
Depending on your project needs, you can choose between two approaches:
Self-service workflow (siRNA):
Design → rank → order directly in the webshop
Expert-supported workflow (ASO / complex siRNA):
Project discussion → design strategy → sequence selection → synthesis
Microsynth offers a fully integrated workflow from sequence design to oligonucleotide production.
Designed sequences can be directly synthesized using our high-quality platforms, enabling rapid progression from design to screening and development.
How to Get Started
- Use the siRNA design tool for standard projects
- Contact our experts for ASO design or complex applications
Start your design project today or request a consultation for advanced oligonucleotide design.
Frequently Asked Questions
In our ASO design, the target sequences are evaluated and selected based on various factors. These include:
- Predicted splicing regulatory elements
- Target binding affinity
- Binding specificity and off target effects
- Sequence properties - GC content, secondary structure
For ASO projects, including splice modulation and exon skipping or complex therapeutic applications.
Yes, Microsynth provides an integrated siRNA design tool with ranking and off-target assessment.