Custom Single-stranded RNA Oligonucleotides

Microsynth offers high-quality single-stranded RNA oligonucleotides for research applications. Our synthesis platform ensures reliable performance, fast turnaround times, and consistent quality.

Applications

Functional genomics
RNA structure and interaction studies
Probe and assay development
In vitro transcription workflows

Why Choose Microsynth RNA Oligos?

High-quality RNA with stringent quality control
Fast and reliable turnaround times
Broad range of modifications
Flexible synthesis scales

Synthesis Scales

We offer five standard RNA oligo synthesis scales ranging from research quantities to high-yield production. Yield depends on sequence length and purification method (click on the blue beam for detailed tables).

Synthesis Scales

Desalted RNA Oligos

Synthesis scale¹	Length Restriction	Guaranteed Yield²		Production Time [wd]
Synthesis scale¹	Length Restriction	[OD260]	[nmol]³	Production Time [wd]
Genomics	not available
0.04 µmol	10 - 30	4	21	2
0.2 µmol	10 - 50	8	35	2
1.0 µmol	10 - 50	18	80	2
15 µmol	10 - 40	400	1'800	3

HPLC Purified RNA Oligos

Synthesis scale¹	Length Restriction	Guaranteed Yield²		Production Time [wd]
Synthesis scale¹	Length Restriction	[OD260]	[nmol]³	Production Time [wd]
Genomics	not available
0.04 µmol	10 - 30	1	5	2
0.2 µmol	10 - 50	3	15	2
1.0 µmol	10 - 50	13	65	2
15 µmol	10 - 40	300	1'500	4

IEX-HPLC Purified RNA Oligos

Synthesis Scale¹	Length Restriction	Guaranteed Yield²		Production Time [wd]
Synthesis Scale¹	Length Restriction	[OD260]	[nmol]⁵	Production Time [wd]
Genomics	not available
0.04 µmol	not available
0.2 µmol	50 - 70	2	3.3	3-5
1.0 µmol	50 - 70	6	10	3-5
15 µmol	not available

RP-HPLC Purified & Dialyzed RNA Oligos

Synthesis scale¹	Length Restriction	Guaranteed Yield²		Production Time [wd]
Synthesis scale¹	Length Restriction	[OD260]	[nmol]³	Production Time [wd]
Genomics	not available
0.04 µmol	not available
0.2 µmol	10 - 50	2	10	4
1.0 µmol	10 - 50	9	45	4
15 µmol	10 - 40	200	1'000	4

PAGE Purified RNA Oligos

Synthesis scale¹	Length Restriction	Guaranteed Yield²		Production Time [wd]
Synthesis scale¹	Length Restriction	[OD260]	[nmol]³	Production Time [wd]
Genomics	not available
0.04 µmol	not available
0.2 µmol	10 - 50	1	5	2
1.0 µmol	10 - 50	6	30	2
15 µmol	not available

¹ The synthesis scale represents the initial amount of 3' bases (starting material).

² Our guaranteed and average yields are measured in OD and are valid only for unmodified oligos >20 and <40 nucleotides.
³ Yields indicated in nmol represent an example calculation for a 20mer. For this calculation the following rule of thumb equation was applied: nmol of oligo = OD x 100/length of oligo. Please note that this calculation is based on sequences with virtually homogenous distribution of the 4 RNA bases.

Available RNA Modifications

Design highly customized oligos with a broad portfolio of 5’, 3’ and internal modifications.

To learn more about the key specifications of a modification, please look at Modifications.

If your desired modification is not listed please contact us for availability.

Quality Control & Manufacturing Standards

Our RNA oligos are produced using state-of-the-art synthesizers and controlled manufacturing processes.

Quality assurance includes:

Controlled synthesis chemistry
In-process monitoring
Final mass verification
Optional analytical documentation

This ensures batch-to-batch consistency and reliable experimental results.

How to Order

Enter our webshop
Click on Single-Stranded RNA in the "DNA/RNA Synthesis" domain
Select either Normal Entry in order to type or copy/paste the desired sequence information etc. or alternatively select Upload Entry by using our convenient Excel Template (can be downloaded during ordering )
Follow the further instructions

To obtain information about our prices, please login to our webshop and download the current price list or ask your sales manager for a specific quote (attractive discounts are available if you plan to order more regularly from Microsynth or if you have a volume order).