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Nucleic Acid Isolation

It is well known in the scientific world that the purity and integrity of the isolated DNA/RNA has a significant impact on the final outcome of downstream genomic analysis.
Therefore, it is of paramount importance to rely on optimized and well-proven isolation systems when performing any kind of genomic analysis.
Microsynth looks back on more than 15 years of experience in DNA/RNA isolation from different and difficult matrices like plant material, soil, food or stool.

Features and Benefits

Experienced and Imaginative
Microsynth has extensive experience with the isolation of nucleic acids from various sample matrixes. Isolation protocols are thoroughly tested and validated before the actual samples are processed. If necessary and depending on your sample new protocols are compiled de novo.
Profit from our experience. Improve your overall productivity by spending more time evolving your experiments and analyzing your data rather than expending time and effort on optimizing your DNA/RNA isolation approach.
One-stop solution. Let Microsynth plan and execute your whole project. From sampling, over nucleic acid isolation to a broad portfolio of genomic analyses you can get everything from one source.
Using our automated isolation methods and critical know-how we are able to process your samples fast and efficient.
Technical Support
Direct access to support by experienced academic staff from Monday – Friday.

Sample Matrices


Microsynth is able to process a large variety of sample matrices and DNA/RNA sources. Our well-proven and validated protocols for nucleic acid isolation ensure that the following 4 steps are professionally handled:

  • Effective disruption of the cellular structure to generate a lysate
  • Clean separation of the soluble nucleic acids from cell debris and other insoluble materials
  • Separation of nucleic acids from soluble proteins
  • Final high-level purification of nucleic acids


Sample Matrix Description
Industry Products
Organic and Inorganic Chemical Products Powders, liquids, gels, complex and demanding chemical composition
Biotechnological Products Robust validated methods fit for purpose
Drug Products Lipid nanoparticles, various biotechnological products for residual DNA testing
Viral Vectors Single stranded or double stranded DNA or RNA viruses
Biological Fluids, Cells and Solid tissues
Cell Culture Animal, supernatants (viral), research cell banks, master cell banks, working cell banks
Animal Soft Tissues & Cells Liver, brain, lung, heart, kindney, spleen
Animal Hard Tissues Bones, teeth, shells
Animal Integumentary System Feathers, hair, fin, exuviae
Body Fluids Blood, lymphocytes, plasma, urine, mucus, cerebrospinal fluid, saliva
Fixed Tissues FFPE and glass-slide samples
Medical Samples Ichor, collections and biobanks
Tough to Lyse
Plants and Seeds Fresh, dried and herbarial samples, wood splints, roots
Fungi Mycelium, fruiting body
Culture Fungal, bacterial, archeal, supernatants (phage)
Environmental (Free) Samples Biofilm, fecal, scat, soil (clay, loam, aquifer sediments, potting soil, sand, sewer slugde, manure, compost, marine sediments), water
Plasmid DNA Purification 
E.coli Mini-, Midi-, Maxi-, Gigaprepscales / BAC, YAC, PAC plasmid
Yeast Miniprepscale
You don't find your sample type on our list?
Please contact us and we will find out how we can help you. 

Added Services

Complex Matrices
You have unusual volumes, shapes, matrices, origins or consistence?
Most probably we have already worked with such samples and developed a standardized isolation protocol.
If not, we will be able to develop a an individual approach.
Sampling/Sample Tracking
To simplify your sampling procedure, we can supply you with the transport vials, transport buffers and containers.
Precise sample tracking with a barcoding system is possible.
For certain project we can assist your field sampling.

Examples of complex samples and sample tracking we have already worked with:
  • High volume liquid samples: water drain samples, environmental aquatic samples (300ml – 1l and more), blood
  • DNA isolation from ash, different kind of soil, stool, scat, biofilm
  • Delivery of the suitable transport vials, transport buffers to the customer
  • Setup and running of a barcoding system
  • Assistance in field sampling

Project Outsourcing

Sample processing and DNA/RNA isolation is often a part of larger and more complex research projects. Microsynth has gathered years of work experience in planning and successfully completing such projects. With the combined knowledge of our different business units we are prepared to manage and realize a plurality of molecular biology projects.
Get in contact with us to see how we can enrich your research.