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Nucleic Acid Isolation from Complex Sample Matrices
High-quality DNA and RNA isolation from a wide range of challenging sample types. Microsynth delivers optimized, validated and custom isolation workflows to ensure reliable downstream genomic analysis.
Why Choose Microsynth?
- Expertise across complex matrices – from environmental samples to pharmaceutical products
- Validated and custom protocols – optimized workflows or de novo method development
- High-quality DNA/RNA – ensuring reliable downstream PCR, sequencing and genomic analyses
- Integrated workflows – from sampling to isolation and downstream analysis
- Scalable and efficient processing – automated methods for fast turnaround
Sample Matrices
Supported Sample Matrices
Microsynth processes a wide range of challenging DNA/RNA sources, including:
| Sample Matrix | Description |
| Industry Products | |
| Organic and Inorganic Chemical Products | Powders, liquids, gels, complex and demanding chemical composition |
| Biotechnological Products | Robust validated methods fit for purpose |
| Drug Products | Lipid nanoparticles, various biotechnological products for residual DNA testing |
| Viral Vectors | Single stranded or double stranded DNA or RNA viruses |
| Biological Fluids, Cells and Solid tissues | |
| Cell Culture | Animal, supernatants (viral), research cell banks, master cell banks, working cell banks |
| Animal Soft Tissues & Cells | Liver, brain, lung, heart, kindney, spleen |
| Animal Hard Tissues | Bones, teeth, shells |
| Animal Integumentary System | Feathers, hair, fin, exuviae |
| Body Fluids | Blood, lymphocytes, plasma, urine, mucus, cerebrospinal fluid, saliva |
| Fixed Tissues | FFPE and glass-slide samples |
| Medical Samples | Ichor, collections and biobanks |
| Tough to Lyse | |
| Plants and Seeds | Fresh, dried and herbarial samples, wood splints, roots |
| Fungi | Mycelium, fruiting body |
| Culture | Fungal, bacterial, archeal, supernatants (phage) |
| Environmental (Free) Samples | Biofilm, fecal, scat, soil (clay, loam, aquifer sediments, potting soil, sand, sewer slugde, manure, compost, marine sediments), water |
| Plasmid DNA Purification | |
| E.coli | Mini-, Midi-, Maxi-, Gigaprepscales / BAC, YAC, PAC plasmid |
| Yeast | Miniprepscale |
You don't find your sample type on our list?
Please contact us and we will find out how we can help you.
Isolation Workflow
All nucleic acid isolation workflows are based on validated processes including:
- Efficient disruption and lysis of cellular structures
- Separation of nucleic acids from debris and contaminants
- Removal of proteins and inhibitors
- Final purification to ensure high-quality DNA/RNA
Additional Services
- Sample preparation support – subsampling and specialized handling
- Sample tracking systems – barcode-based tracking and documentation
- Supply of sampling materials – tubes, buffers and transport containers
- Field sampling support – assistance for complex sampling workflows