Spacers (for DNA)

 

The C3 Spacer phosphoramidite can be incorporated internally or at the 3'-end of the oligo. Multiple C3 spacers can be added at the 3'-end of an oligo to introduce a long hydrophilic spacer arm for the attachment of fluorophores or other pendent groups.

 

 

 

 

Spacer 18 is an 18-atom hexa-ethyleneglycol spacer. It is the longest spacer arm that can be added as a single modification.

 

 

 

 

Spacer C12 is a 12-carbon spacer that is used to incorporate a long spacer arm into an oligonucleotide. Spacer C12 is frequently used for solid-phase immobilization of DNA probes or aptamers for microarray applications, but can be used for any oligonucleotide-based application requiring a long spacer arm.

 

 

 

 

The 1’,2’-Dideoxyribose modification is used to introduce a stable abasic site within an oligonucleotide.