Back to top

Bioactive Labels (for DNA)

 
Bioactive Labels
Position
 
5’
3’
int
Biotin / Biotin-dT
X
X
X
Digoxigenin / Digoxigenin-dT
X
X
X
Cholesterol  
X
 
GalNAc  
X
 
 

Biotin / Biotin-dT

Biotin
Biotin-TEG
Biotin-TEG
Biotin-dT
Biotin-dT
 
Label for binding oligos to streptavidin.
 
Bioactive Modification
Position
Synthesis Scale [µmol]
Purification
 
 
0.04
0.2
1.0
15
Des
HPLC
IEX
PAGE
Biotin / Biotin-TEG
5’
X X X O   X X X
Biotin-TEG
3’
  X X O   X X X
Biotin-dT
Int
  X X O
 
X X X
X = available/on stock
O = on request
 

Digoxigenin / Digoxigenin-dT

Digoxigenin is a hapten, a small molecule with high antigenicity, that is used in many molecular biology applications similarly to other popular haptens such as 2,4-Dinitrophenol, biotin, and fluorescein. Digoxigenin is thus an all-purpose immuno-tag.

 
Bioactive Modification
Position
Synthesis Scale [µmol]
Purification
 
 
0.04
0.2
1.0
15
Des
HPLC
PAGE
Digoxigenin
5’
  X X O   X X
3’
  X X O   X X
Digoxigenin-dT
Int
  X X O
 
X X
X = available/on stock
O = on request
 

Cholesterol

Cholesterol
 

Cholesterol is used to improve cellular uptake. By conjugating oligonucleotides to the non-toxic and hydrophobic cholesterol the oligonucleotide permeates better through the cell membrane.

 
Position
Synthesis Scale [µmol]
Purification
 
0.04
0.2
1.0
15
Des
HPLC
PAGE
3'  
X
X
O  
X
X
X = available/on stock
O = on request
 

N-acetylgalactosamine (GalNAc)

 

Conjugation of N-acetylgalactosamine (GalNAc) has become a major clinical strategy for delivery of oligonucleotides to hepatocytes (liver cells). Such conjugates are efficiently internalized by binding to the asialoglycoprotein receptor (ASGR), which exhibits high affinity for N-acetyl galactosamine terminated oligosaccharides.

 
Position
Synthesis Scale [µmol]
Purification
 
0.04
0.2
1.0
15
Des
HPLC
HPLC & Dialysis
3'  
X
X
O  
X
X
X = available/on stock
O = on request