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Bioactive Labels (for RNA)
|
Bioactive Labels
|
Position
|
||
|
|
5’
|
3’
|
int
|
| Biotin |
X
|
X
|
|
| Digoxigenin |
X
|
X
|
|
| Cholesterol |
X
|
X
|
|
Biotin
Label for binding oligos to streptavidin.
| Bioactive Modification |
Position
|
Synthesis Scale [µmol]
|
Purification
|
|||||
|
|
0.04
|
0.2
|
1.0
|
15
|
Des
|
HPLC
|
PAGE
|
|
| Biotin |
5’
|
X | X | X | O | X | X | |
|
3’
|
X | X | O | X | X | |||
X = available/on stock
O = on request
Digoxigenin
Digoxigenin is a hapten, a small molecule with high antigenicity, that is used in many molecular biology applications similarly to other popular haptens such as 2,4-Dinitrophenol, biotin, and fluorescein. Digoxigenin is thus an all-purpose immuno-tag.
|
Bioactive Modification
|
Position
|
Synthesis Scale [µmol]
|
Purification
|
|||||
|
|
0.04
|
0.2
|
1.0
|
15
|
Des
|
HPLC
|
PAGE
|
|
| Digoxigenin |
5’
|
X | X | O | X | X | ||
|
3’
|
X | X | O | X | X | |||
X = available/on stock
O = on request
Cholesterol
Cholesterol is used to improve cellular uptake. By conjugating oligonucleotides to the non-toxic and hydrophobic cholesterol the oligonucleotide permeates better through the cell membrane.
|
Position
|
Synthesis Scale [µmol]
|
Purification
|
|||||
|
|
0.04
|
0.2
|
1.0
|
15
|
Des
|
HPLC
|
PAGE
|
| 3' |
X
|
X
|
O |
X
|
X | ||
X = available/on stock
O = on request