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Etiquettes Bioactives (pour les OSAs)

 
Bioactive Lables
Position
 
5’
3’
int
Cholesterol  
on request
 
GalNAc  
on request
 
 

Cholesterol

Cholesterol
 

Cholesterol is used to improve cellular uptake. By conjugating oligonucleotides to the non-toxic and hydrophobic cholesterol the oligonucleotide permeates better through the cell membrane.

 
Position
Synthesis Scale [µmol]
Purification
 
0.04
0.2
1.0
15
Des
HPLC
PAGE
3'  
X
X
O  
X
X
X = available/on stock
O = on request
 

N-acetylgalactosamine (GalNAc)

 

Conjugation of N-acetylgalactosamine (GalNAc) has become a major clinical strategy for delivery of oligonucleotides to hepatocytes (liver cells). Such conjugates are efficiently internalized by binding to the asialoglycoprotein receptor (ASGR), which exhibits high affinity for N-acetyl galactosamine terminated oligosaccharides.

 
Position
Synthesis Scale [µmol]
Purification
 
0.04
0.2
1.0
15
Des
HPLC
HPLC & Dialysis
3'  
X
X
O  
X
X
X = available/on stock
O = on request